Endocrine Abstracts

Atherosclerotic cardiovascular disease (ASCVD) is a chronic inflammatory disorder characterised by the gradual build-up of plaques in the arterial wall. Unstable plaques are more dangerous than stable plaques as they are prone to rupture and obstruct blood flow, resulting in heart attacks and strokes. Lipids play a key role in plaque progression, yet their exact involvement remains elusive. We hypothesise that stable or unstable plaques will have distinct spatial lipid phenoty...

Atherosclerosis, a multifaceted cardiovascular disease characterised by fatty plaque buildup in large and medium-sized arteries, is a leading cause of heart attacks, strokes and peripheral arterial disease. Its global impact on morbidity and mortality rates poses a significant health challenge. This study aimed to comprehensively understand its complex pathogenesis using histologically aided Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry Imaging (MALDI-MSI) to e...